Title : Downregulation of survivin and aurora A by histone deacetylase and RAS inhibitors: a new drug combination for cancer therapy.

Pub. Date : 2011 Feb 1

PMID : 20473860






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Here, we examined whether the combined application of VPA and FTS could synergistically inhibit the proliferation of cancer cells that express oncogenic K-Ras (A549 nonsmall-cell lung carcinoma cells), DLD1 (colon carcinoma cells) or chronically active wild-type K-Ras and constitutively active B-Raf (ARO, thyroid carcinoma cells). farnesylthiosalicylic acid KRAS proto-oncogene, GTPase Homo sapiens