Title : Functional characterisation of cell cycle-related kinase (CCRK) in colorectal cancer carcinogenesis.

Pub. Date : 2010 Jun

PMID : 20466538






2 Functional Relationships(s)
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1 Furthermore, we showed that CCRK is required for the phosphorylation of Cdk2 (on Thr-160) and Rb (on Ser-795) and the expression of cyclin E. These results suggest for the first time that CCRK is involved in colorectal cancer carcinogenesis and G1/S cell cycle transition by regulating Cdk2, cyclin E and Rb. Serine cyclin dependent kinase 2 Homo sapiens
2 Furthermore, we showed that CCRK is required for the phosphorylation of Cdk2 (on Thr-160) and Rb (on Ser-795) and the expression of cyclin E. These results suggest for the first time that CCRK is involved in colorectal cancer carcinogenesis and G1/S cell cycle transition by regulating Cdk2, cyclin E and Rb. Serine cyclin dependent kinase 2 Homo sapiens