Pub. Date : 2011 Apr
PMID : 20458531
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We here demonstrate that the anti-diabetic drug metformin interacts synergistically with the anti-HER2 monoclonal antibody trastuzumab (Tzb; Herceptin ) to eliminate stem/progenitor cell populations in HER2-gene-amplified breast carcinoma cells. | Metformin | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |
| 2 | We here demonstrate that the anti-diabetic drug metformin interacts synergistically with the anti-HER2 monoclonal antibody trastuzumab (Tzb; Herceptin ) to eliminate stem/progenitor cell populations in HER2-gene-amplified breast carcinoma cells. | Metformin | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |
| 3 | When using the mammosphere culture technique, graded concentrations of single-agent metformin (range 50-1,000 mumol/l) were found to dose-dependently reduce the number of mammospheres formed by SKBR3 (a Tzb-naive model), SKBR3 TzbR (a model of acquired auto-resistance to Tzb) and JIMT-1 (a model of refractoriness to Tzb and other HER2-targeted therapies ab initio) HER2-overexpressing breast cancer cells. | Metformin | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |
| 4 | When using the mammosphere culture technique, graded concentrations of single-agent metformin (range 50-1,000 mumol/l) were found to dose-dependently reduce the number of mammospheres formed by SKBR3 (a Tzb-naive model), SKBR3 TzbR (a model of acquired auto-resistance to Tzb) and JIMT-1 (a model of refractoriness to Tzb and other HER2-targeted therapies ab initio) HER2-overexpressing breast cancer cells. | Metformin | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |