Title : Role of hydrogen sulfide production in inhibitory action of L-cysteine on isolated porcine irides.

Pub. Date : 2010 May

PMID : 20450253






2 Functional Relationships(s)
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1 Both the inhibitor of cystathionine beta-synthase, AOA (30 microM) and the K(ATP) channel antagonist, glibenclamide (100 microM) caused significant (P < 0.001) rightward shifts in the concentration-response curves to L-cysteine and attenuated the maximum inhibitory response. Cysteine cystathionine beta-synthase Homo sapiens
2 CONCLUSIONS: The inhibitory action of L-cysteine in isolated porcine irides is dependent on the endogenous production of H(2)S by cystathionine gamma-lyase and cystathionine beta-synthase. Cysteine cystathionine beta-synthase Homo sapiens