Title : New insights into the antifibrotic effects of sorafenib on hepatic stellate cells and liver fibrosis.

Pub. Date : 2010 Jul

PMID : 20447716






1 Functional Relationships(s)
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1 Moreover, sorafenib downregulated Cyclin D1 and Cyclin-dependent kinase 4 (Cdk-4), simultaneously increased expression of Fas, Fas-L, and Caspase-3, and decreased the ratio of Bcl-2 to Bax. Sorafenib caspase 3 Rattus norvegicus