Title : Assessment of competitive and mechanism-based inhibition by clarithromycin: use of domperidone as a CYP3A probe-drug substrate and various enzymatic sources including a new cell-based assay with freshly isolated human hepatocytes.

Pub. Date : 2010 Apr

PMID : 20446912






2 Functional Relationships(s)
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Protein Name
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1 At high concentrations (100 microM), clarithromycin had weak competitive inhibition potency towards CYP3A4 and CYP3A5. Clarithromycin cytochrome P450 family 3 subfamily A member 4 Homo sapiens
2 Drug interactions between clarithromycin and several CYP3A substrates are predicted to be insidious; the risk of severe adverse events should increase over time and persist for a few days after cessation of the drug. Clarithromycin cytochrome P450 family 3 subfamily A member 4 Homo sapiens