PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20444542-11 2010 Inhibition of PI3K/Akt signaling pathway restored sensitivity to gefitinib in HCC827-CR cells. Gefitinib 65-74 AKT serine/threonine kinase 1 Homo sapiens 19-22 20444542-12 2010 Taken together, these data show that PTEN instability-mediated constitutive Akt activation is involved in acquired resistance mechanisms to cetuximab and also induces de novo resistance to gefitinib. Gefitinib 189-198 AKT serine/threonine kinase 1 Homo sapiens 76-79