Title : Mitogen-activated protein kinases pathway is involved in physiological testosterone-induced tissue factor pathway inhibitor expression in endothelial cells.

Pub. Date : 2010 Jul

PMID : 20442653






5 Functional Relationships(s)
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1 Mitogen-activated protein kinases pathway is involved in physiological testosterone-induced tissue factor pathway inhibitor expression in endothelial cells. Testosterone tissue factor pathway inhibitor Homo sapiens
2 The mechanism of testosterone inducing the tissue factor pathway inhibitor (TFPI) in protecting against thrombosis is unknown. Testosterone tissue factor pathway inhibitor Homo sapiens
3 The mechanism of testosterone inducing the tissue factor pathway inhibitor (TFPI) in protecting against thrombosis is unknown. Testosterone tissue factor pathway inhibitor Homo sapiens
4 Blocking ERK1/2 or JNK pathway could significantly impair testosterone-induced TFPI at both translational and transcriptional levels in HUVECs. Testosterone tissue factor pathway inhibitor Homo sapiens
5 Testosterone at a physiological concentration may help to prevent thrombosis development by stimulating TFPI expression in HUVECs, partly through the ERK1/2 and JNK MAPK pathway. Testosterone tissue factor pathway inhibitor Homo sapiens