Title : Chlamydial infection of monocytes stimulates IL-1beta secretion through activation of the NLRP3 inflammasome.

Pub. Date : 2010 Aug

PMID : 20434582






1 Functional Relationships(s)
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1 Thus, secretion of IL-1beta decreased significantly when cells were depleted of NLRP3 or treated with the anti-inflammatory inhibitors parthenolide or Bay 11-7082, which inhibit inflammasomes and the transcription factor NF-kappaB. parthenolide nuclear factor kappa B subunit 1 Homo sapiens