Pub. Date : 2010 Jul
PMID : 20430876
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Gene ablation for PEPT1 in mice abolishes the effects of dipeptides on small intestinal fluid absorption, short-circuit current, and intracellular pH. | Dipeptides | solute carrier family 15 (oligopeptide transporter), member 1 | Mus musculus |
| 2 | The dipeptide-induced increase in fluid absorption in vivo was also abolished in animals lacking PEPT1. | Dipeptides | solute carrier family 15 (oligopeptide transporter), member 1 | Mus musculus |
| 3 | This study demonstrates for the first time that proton-coupled electrogenic dipeptide uptake in the native small intestine, mediated by PEPT1, relies on the negative apical membrane potential as the major driving force and contributes significantly to intestinal fluid transport. | Dipeptides | solute carrier family 15 (oligopeptide transporter), member 1 | Mus musculus |