Pub. Date : 2010
PMID : 20424383
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | alpha-Viniferin suppresses the signal transducer and activation of transcription-1 (STAT-1)-inducible inflammatory genes in interferon-gamma-stimulated macrophages. | alpha-viniferin | interferon gamma | Mus musculus |
| 2 | alpha-Viniferin at 3 - 10 muM dose-dependently inhibited IFN-gamma-induced production of NO, IFN-gamma-inducible protein-10 (IP-10), or the monokine induced by IFN-gamma (MIG) in RAW 264.7 cells and also that of NO in primary macrophages-derived from C57BL/6 mice. | alpha-viniferin | interferon gamma | Mus musculus |
| 3 | Furthermore, alpha-viniferin diminished IFN-gamma-induced protein levels of inducible NO synthase (iNOS), attenuated mRNA levels of iNOS, IP-10, or MIG as well as inhibited promoter activity of the iNOS gene. | alpha-viniferin | interferon gamma | Mus musculus |
| 4 | In conclusion, this study proposes an anti-inflammatory mechanism of alpha-viniferin, down-regulating STAT-1-inducible inflammatory genes via inhibiting ERK-mediated STAT-1 activation in IFN-gamma-stimulated macrophages. | alpha-viniferin | interferon gamma | Mus musculus |