PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20424383-0 2010 alpha-Viniferin suppresses the signal transducer and activation of transcription-1 (STAT-1)-inducible inflammatory genes in interferon-gamma-stimulated macrophages. alpha-viniferin 0-15 interferon gamma Mus musculus 124-140 20424383-6 2010 alpha-Viniferin at 3 - 10 muM dose-dependently inhibited IFN-gamma-induced production of NO, IFN-gamma-inducible protein-10 (IP-10), or the monokine induced by IFN-gamma (MIG) in RAW 264.7 cells and also that of NO in primary macrophages-derived from C57BL/6 mice. alpha-viniferin 0-15 interferon gamma Mus musculus 57-66 20424383-7 2010 Furthermore, alpha-viniferin diminished IFN-gamma-induced protein levels of inducible NO synthase (iNOS), attenuated mRNA levels of iNOS, IP-10, or MIG as well as inhibited promoter activity of the iNOS gene. alpha-viniferin 13-28 interferon gamma Mus musculus 40-49 20424383-8 2010 In conclusion, this study proposes an anti-inflammatory mechanism of alpha-viniferin, down-regulating STAT-1-inducible inflammatory genes via inhibiting ERK-mediated STAT-1 activation in IFN-gamma-stimulated macrophages. alpha-viniferin 69-84 interferon gamma Mus musculus 187-196