Title : Sigma-1 receptor-induced increase in murine spinal NR1 phosphorylation is mediated by the PKCalpha and epsilon, but not the PKCzeta, isoforms.

Pub. Date : 2010 Jun 21

PMID : 20417251






1 Functional Relationships(s)
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1 Intrathecal pretreatment with inhibitors (Go6976, PKCepsilonV1-2 or PKC zetapseudosubstrate) of the PKCalpha, epsilon or zeta isoforms significantly reduced the PRE-induced pain facilitatory effect. Go 6976 protein kinase C, alpha Mus musculus