Pub. Date : 2010 Jun 3
PMID : 20416296
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Icariin, a flavonoid isolated from Epimedii herba, stimulated phosphorylation of endothelial nitric oxide synthase (eNOS) at Ser1177, Akt (Ser473) and ERK1/2 (Thr202/Tyr204). | icariin | mitogen-activated protein kinase 3 | Homo sapiens |
| 2 | The icariin-induced eNOS phosphorylation was inhibited by wortmannin, a phosphatidylinositol 3-kinase (PI3K) inhibitor and partially attenuated by PD98059, an upstream inhibitor for ERK1/2. | icariin | mitogen-activated protein kinase 3 | Homo sapiens |
| 3 | PI3K/Akt and MAPK-ERK kinase (MEK)/ERK1/2 pathways were involved in the phosphorylation of eNOS by icariin. | icariin | mitogen-activated protein kinase 3 | Homo sapiens |