Pub. Date : 2010 May 28
PMID : 20416277
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Here, we unveil a new action of hinokitiol, an iron chelator found in natural plants, on stabilization of HIF-1alpha in cell cultures in a dose-dependent manner. | beta-thujaplicin | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
| 2 | In vitro PHD2 and FIH activity assays based on fluorescence polarization reveal that such HIF-1alpha stabilization is likely medicated by inhibitory effects of hinokitiol on prolyl and asparaginyl hydroxylation of HIF-1alpha. | beta-thujaplicin | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
| 3 | In vitro PHD2 and FIH activity assays based on fluorescence polarization reveal that such HIF-1alpha stabilization is likely medicated by inhibitory effects of hinokitiol on prolyl and asparaginyl hydroxylation of HIF-1alpha. | beta-thujaplicin | hypoxia inducible factor 1 subunit alpha | Homo sapiens |