Title : Neuroendocrine nicotinic receptor activation increases susceptibility to bacterial infections by suppressing antimicrobial peptide production.

Pub. Date : 2010 Apr 22

PMID : 20413096






1 Functional Relationships(s)
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1 These data identify a mechanism for the negative regulation of host-innate AMP response to infection through cholinergic activation and indicate nAChR-mediated cathelicidin dysregulation as a potential mechanism for increased susceptibility to infection following prolonged stress or nicotine use. Nicotine cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus