Title : Structure-activity relationships of fluorinated (E)-3-((6-methylpyridin-2-yl)ethynyl)cyclohex-2-enone-O-methyloxime (ABP688) derivatives and the discovery of a high affinity analogue as a potential candidate for imaging metabotropic glutamate recepors subtype 5 (mGluR5) with positron emission tomography (PET).

Pub. Date : 2010 May 27

PMID : 20411954






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 In an effort to obtain a fluorine-18 labeled analogue of the mGluR5 PET tracer [(11)C]ABP688, 13 novel ligands based on the core structure of ABP688 were synthesized. Fluorine-18 glutamate receptor, ionotropic, kainate 1 Mus musculus