Title : The tumor-suppressive function of Connexin43 in keratinocytes is mediated in part via interaction with caveolin-1.

Pub. Date : 2010 May 15

PMID : 20406988






2 Functional Relationships(s)
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1 We now show that rat epidermal keratinocytes (REK) that are reduced in Cx43 present features of epithelial-to-mesenchymal transition and are more invasive than their control counterparts, whereas overexpression of Cx43 inhibited the 12-O-tetradecanoyl-phorbol-13-acetate (TPA)- and epidermal growth factor (EGF)-induced invasive properties. Tetradecanoylphorbol Acetate gap junction protein, alpha 1 Rattus norvegicus
2 We now show that rat epidermal keratinocytes (REK) that are reduced in Cx43 present features of epithelial-to-mesenchymal transition and are more invasive than their control counterparts, whereas overexpression of Cx43 inhibited the 12-O-tetradecanoyl-phorbol-13-acetate (TPA)- and epidermal growth factor (EGF)-induced invasive properties. Tetradecanoylphorbol Acetate gap junction protein, alpha 1 Rattus norvegicus