Title : Hepatic uptake of the magnetic resonance imaging contrast agent Gd-EOB-DTPA: role of human organic anion transporters.

Pub. Date : 2010 Jul

PMID : 20406852






2 Functional Relationships(s)
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1 In competition assays, Gd-EOB-DTPA inhibited the uptake of bromosulfophthalein (BSP) by OATP1B1 (IC(50) = 0.6 mM) and OATP1B3 (IC(50) = 0.4 mM). gadolinium ethoxybenzyl DTPA solute carrier organic anion transporter family member 1B3 Homo sapiens
2 In conclusion, Gd-EOB-DTPA is a substrate of the liver-specific OATP1B1, OATP1B3, and NTCP. gadolinium ethoxybenzyl DTPA solute carrier organic anion transporter family member 1B3 Homo sapiens