Title : Protective effect of sulforaphane on human vascular endothelial cells against lipopolysaccharide-induced inflammatory damage.

Pub. Date : 2010 Jun

PMID : 20405237






3 Functional Relationships(s)
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1 Moreover, sulforaphane suppressed the phosphorylation of ERK1/2, JNK, and p38 activated by lipopolysaccharide. sulforaphane mitogen-activated protein kinase 8 Homo sapiens
2 Moreover, pretreatment with anisomycin (AM), an activator of p38 and JNK, instead of LPS, the expression of COX-2 and iNOS is still inhibited by sulforaphane. sulforaphane mitogen-activated protein kinase 8 Homo sapiens
3 Taken together, these data indicated that sulforaphane exhibited the protective role against the inflammatory injury in vascular endothelia cells, through inactivating p38 MAPK and JNK, as well as inducing phase 2 enzymes. sulforaphane mitogen-activated protein kinase 8 Homo sapiens