Pub. Date : 2010 Jun 21
PMID : 20403340
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Curcumin (10 microg/ml) was found to significantly inhibit the apoptosis of preOL and expression of either iNOS or NOX in the LPS-activated microglia. | Curcumin | nitric oxide synthase 2 | Rattus norvegicus |
| 2 | Treatment with curcumin either 1h before or immediately after LPS injection significantly ameliorated white matter injury and loss of preOLs, decreased activated microglia, and inhibited microglial expression of iNOS and translocation of p67phox and gp91phox to the microglial cell membranes in neonatal rat brains following LPS injection. | Curcumin | nitric oxide synthase 2 | Rattus norvegicus |
| 3 | These results suggest that curcumin has a protective effect on infection-driven white matter injury, which is associated with suppression of iNOS and NOX activation. | Curcumin | nitric oxide synthase 2 | Rattus norvegicus |