Pub. Date : 2010 Jul 16
PMID : 20400503
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Leukotriene B4 is a physiologically relevant endogenous peroxisome proliferator-activated receptor-alpha agonist. | Leukotriene B4 | peroxisome proliferator activated receptor alpha | Mus musculus |
| 2 | Subsequent studies show both in vitro and in a murine model of inflammation that 5-lipoxygenase stimulation induces PPAR-alpha signaling and that this results specifically from production of the inflammatory mediator and chemoattractant leukotriene B(4) (LTB(4)). | Leukotriene B4 | peroxisome proliferator activated receptor alpha | Mus musculus |
| 3 | We also show that the LTB(4) precursors leukotriene A(4) (LTA(4)) and 5-hydroperoxyeicosatetrenoic acid (5-HPETE) activate PPAR-alpha but have no significant endogenous effect independent of conversion to LTB(4). | Leukotriene B4 | peroxisome proliferator activated receptor alpha | Mus musculus |