Pub. Date : 2010
PMID : 20389030
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Octreotide and rapamycin induced a significant decrease in VEGF production by all three cell lines; LY294002 significantly inhibited VEGF production by STC-1 and INS-r3 only. | Sirolimus | vascular endothelial growth factor A | Rattus norvegicus |
| 2 | By Western blotting analysis, we observed decreased intracellular levels of VEGF and HIF-1alpha under octreotide, rapamycin and LY294002. | Sirolimus | vascular endothelial growth factor A | Rattus norvegicus |
| 3 | For rapamycin and LY294002, this effect was likely mediated by the inhibition of the mTOR/HIF-1/VEGF pathway. | Sirolimus | vascular endothelial growth factor A | Rattus norvegicus |
| 4 | In conclusion, our study points out to the complex regulation of VEGF synthesis and secretion in neoplastic GEP endocrine cells and suggests that the inhibition of VEGF production by octreotide and rapamycin may contribute to their therapeutic effects. | Sirolimus | vascular endothelial growth factor A | Rattus norvegicus |