Pub. Date : 2010 Apr
PMID : 20371726
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Vinblastine induces acute, cell cycle phase-independent apoptosis in some leukemias and lymphomas and can induce acute apoptosis in others when Mcl-1 is suppressed. | Vinblastine | MCL1 apoptosis regulator, BCL2 family member | Homo sapiens |
| 2 | Vinblastine induced the rapid induction of Mcl-1 that was inhibited by PD98059 and cycloheximide. | Vinblastine | MCL1 apoptosis regulator, BCL2 family member | Homo sapiens |
| 3 | We hypothesize that ML-1 cells use Mcl-1 for protection from the rapid vinblastine-induced apoptosis. | Vinblastine | MCL1 apoptosis regulator, BCL2 family member | Homo sapiens |
| 4 | Two additional cell lines were sensitized to vinblastine by PD98059, which suppressed Mcl-1. | Vinblastine | MCL1 apoptosis regulator, BCL2 family member | Homo sapiens |