Pub. Date : 2010 Jun
PMID : 20363884
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Further studies indicated that the Dox-induced higher levels of Hsp25 transactivated p53 leading to higher levels of the pro-apoptotic protein Bax, but other p53-related proteins remained unaltered. | Doxorubicin | BCL2-associated X protein | Mus musculus |
| 2 | From these results we propose a novel mechanism for Dox-induced heart failure: increased expression of Hsp25 because of oxidant-induced activation of HSF-1 transactivates p53 to increase Bax levels, which leads to heart failure. | Doxorubicin | BCL2-associated X protein | Mus musculus |