Title : A prodrug approach towards the development of tricyclic-based FBPase inhibitors.

Pub. Date : 2010 May 1

PMID : 20359891






1 Functional Relationships(s)
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1 Extensive SAR studies led to the discovery of pyridine-containing cyclic prodrug 20, which strongly inhibited glucose production in monkey hepatocytes and also showed weak CYP3A4 inhibitory potency. pyridine cytochrome P450 family 3 subfamily A member 4 Homo sapiens