Pub. Date : 2010 Apr 13
PMID : 20354524
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | A multiplexed RT-PCR assay was used to identify KRAS-controlled apoptosis regulators after exposure to 5-FU or oxaliplatin. | Oxaliplatin | KRAS proto-oncogene, GTPase | Homo sapiens |
| 2 | RESULTS: Oncogenic KRAS sensitised colorectal tumour cells to oxaliplatin and 5-FU in a p53-dependent manner and promoted p53 phosphorylation at Ser37 and Ser392, without affecting p53 stabilisation, p21 induction, or cell-cycle arrest. | Oxaliplatin | KRAS proto-oncogene, GTPase | Homo sapiens |
| 3 | CONCLUSION: Oncogenic KRAS determines the cellular response to p53 activation by oxaliplatin or 5-FU, by facilitating apoptosis induction through Noxa. | Oxaliplatin | KRAS proto-oncogene, GTPase | Homo sapiens |