Title : Nitric oxide increases cyclic GMP levels, AMP-activated protein kinase (AMPK)alpha1-specific activity and glucose transport in human skeletal muscle.

Pub. Date : 2010 Jun

PMID : 20349036






4 Functional Relationships(s)
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1 Consistent with this, spermine NONOate increased AMP-activated protein kinase (AMPK)-alpha1-associated activity (1.7-fold, p < 0.05). spermine nitric oxide complex protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens
2 Consistent with this, spermine NONOate increased AMP-activated protein kinase (AMPK)-alpha1-associated activity (1.7-fold, p < 0.05). spermine nitric oxide complex protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens
3 Spermine NONOate also elicited a concomitant increase in AMPK and acetyl-CoA carboxylase phosphorylation. spermine nitric oxide complex protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens
4 CONCLUSIONS/INTERPRETATION: Pharmacological treatment of skeletal muscle with spermine NONOate increases glucose transport via insulin-independent signalling pathways involving increased intracellular cGMP levels and AMPK-alpha1-associated activity. spermine nitric oxide complex protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens