Title : Amide-based inhibitors of p38alpha MAP kinase. Part 1: discovery of novel N-pyridyl amide lead molecules.

Pub. Date : 2010 Apr 15

PMID : 20346653






1 Functional Relationships(s)
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1 Based on the structural similarities between the initial hit and a well-known imidazole pyrimidine series of p38alpha inhibitors, potencies within the newly discovered series were quickly improved by installation of an (S)-alpha-methylbenzyl moiety at the 2-position of the pyridine ring. pyridine mitogen-activated protein kinase 14 Homo sapiens