Pub. Date : 2010 Mar
PMID : 20335103
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | [Effect of glutamate on vascular endothelial growth factor mRNA and protein expressions in hypoxic rat astrocytes in vitro]. | Glutamic Acid | vascular endothelial growth factor A | Rattus norvegicus |
| 2 | OBJECTIVE: To study the effect of glutamate on the expression of vascular endothelial growth factor (VEGF) mRNA and protein in cultured rat astrocytes under hypoxia. | Glutamic Acid | vascular endothelial growth factor A | Rattus norvegicus |
| 3 | OBJECTIVE: To study the effect of glutamate on the expression of vascular endothelial growth factor (VEGF) mRNA and protein in cultured rat astrocytes under hypoxia. | Glutamic Acid | vascular endothelial growth factor A | Rattus norvegicus |
| 4 | RESULTS: The expressions of VEGF mRNA and protein underwent no significant changes in the control glutamate groups, but increased obviously in both hypoxia and hypoxia+glutamate groups at 2, 4, 6, 8 and 12 h of hypoxic exposure. | Glutamic Acid | vascular endothelial growth factor A | Rattus norvegicus |
| 5 | RESULTS: The expressions of VEGF mRNA and protein underwent no significant changes in the control glutamate groups, but increased obviously in both hypoxia and hypoxia+glutamate groups at 2, 4, 6, 8 and 12 h of hypoxic exposure. | Glutamic Acid | vascular endothelial growth factor A | Rattus norvegicus |
| 6 | At these time points, VEGF expressions at both the mRNA and protein levels were significantly higher in hypoxia+glutamate group than in hypoxia group. | Glutamic Acid | vascular endothelial growth factor A | Rattus norvegicus |
| 7 | CONCLUSION: Glutamate at 1 micromol/L can further increase the expression of VEGF mRNA and protein in astrocytes exposed to hypoxia, which may result from the adaptive changes of glutamate receptors in hypoxic astrocytes. | Glutamic Acid | vascular endothelial growth factor A | Rattus norvegicus |