Title : Pre-clinical properties of the alpha4beta2 nicotinic acetylcholine receptor partial agonists varenicline, cytisine and dianicline translate to clinical efficacy for nicotine dependence.

Pub. Date : 2010 May

PMID : 20331614






1 Functional Relationships(s)
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1 CONCLUSIONS AND IMPLICATIONS: The data provide a plausible explanation for the higher abstinence rate in smoking cessation trials following treatment with varenicline than with the two other alpha4beta2 nAChR partial agonists. Varenicline cholinergic receptor nicotinic alpha 4 subunit Homo sapiens