Title : The cytoplasmic domains of TNFalpha-converting enzyme (TACE/ADAM17) and L-selectin are regulated differently by p38 MAPK and PKC to promote ectodomain shedding.

Pub. Date : 2010 May 13

PMID : 20331435






1 Functional Relationships(s)
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1 By using PMA and the phosphatase inhibitors cantharidin and calyculin A, we could selectively activate PKC or p38 MAPK respectively to promote TACE-dependent shedding of L-selectin. Tetradecanoylphorbol Acetate mitogen-activated protein kinase 14 Homo sapiens