Pub. Date : 1991 Jan
PMID : 2030746
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Therefore, we studied the effects of the calmodulin antagonists fendiline and calmidazolium on the thrombin-induced aggregation, secretion of ATP, and increases in the intracellular free calcium concentration ([Ca2+]i) in washed human platelets in the absence and presence of extracellular Ca2+. | Fendiline | coagulation factor II, thrombin | Homo sapiens |
| 2 | The effect of fendiline could be partly reversed by extracellular Ca2+ and higher thrombin concentrations. | Fendiline | coagulation factor II, thrombin | Homo sapiens |
| 3 | Furthermore, aggregations induced by the calcium ionophore ionomycin and by the protein kinase C-activator 4-beta-phorbol 12-myristate 13-acetate were inhibited by fendiline, although to a smaller degree than the thrombin-induced aggregation. | Fendiline | coagulation factor II, thrombin | Homo sapiens |
| 4 | Thrombin-induced secretion of ATP was attenuated by low concentrations of fendiline (1-3 microM) and calmidazolium (1 microM) but enhanced by higher concentrations (10-30 and 3-10 microM, respectively), independently of extracellular Ca2+. | Fendiline | coagulation factor II, thrombin | Homo sapiens |