Title : Oral delivery of PND-1186 FAK inhibitor decreases tumor growth and spontaneous breast to lung metastasis in pre-clinical models.

Pub. Date : 2010 May 15

PMID : 20234193






3 Functional Relationships(s)
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1 Here, we show that the FAK inhibitor PND-1186 blocks FAK Tyr-397 phosphorylation in vivo and exhibits anti-tumor efficacy in orthotopic breast carcinoma mouse tumor models. Tyrosine PTK2 protein tyrosine kinase 2 Mus musculus
2 Here, we show that the FAK inhibitor PND-1186 blocks FAK Tyr-397 phosphorylation in vivo and exhibits anti-tumor efficacy in orthotopic breast carcinoma mouse tumor models. Tyrosine PTK2 protein tyrosine kinase 2 Mus musculus
3 showed promising pharmacokinetics (PK) and inhibited tumor FAK Tyr-397 phosphorylation for 12 hours. Tyrosine PTK2 protein tyrosine kinase 2 Mus musculus