Title : PND-1186 FAK inhibitor selectively promotes tumor cell apoptosis in three-dimensional environments.

Pub. Date : 2010 May 15

PMID : 20234191






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 As increased FAK expression and tyrosine phosphorylation are associated with tumor progression, inhibitors of FAK are being tested for anti-tumor effects. Tyrosine PTK2 protein tyrosine kinase 2 Mus musculus
2 PND-1186 has an IC50 of ~100 nM in breast carcinoma cells as determined by anti-phospho-specific immunoblotting to FAK Tyr-397. Tyrosine PTK2 protein tyrosine kinase 2 Mus musculus