Title : Pharmacokinetic and pharmacodynamic interactions between the immunosuppressant sirolimus and the lipid-lowering drug ezetimibe in healthy volunteers.

Pub. Date : 2010 Jun

PMID : 20220747






2 Functional Relationships(s)
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1 Adverse pharmacokinetic interactions are hypothesized with sirolimus, which is a substrate of OATP1B1 and OATP1B3 and an inhibitor of ABCB1, OATP1B1, and OATP1B3 but not of ABCC2. Sirolimus solute carrier organic anion transporter family member 1B1 Homo sapiens
2 Adverse pharmacokinetic interactions are hypothesized with sirolimus, which is a substrate of OATP1B1 and OATP1B3 and an inhibitor of ABCB1, OATP1B1, and OATP1B3 but not of ABCC2. Sirolimus solute carrier organic anion transporter family member 1B1 Homo sapiens