Pub. Date : 2010 Apr
PMID : 20216337
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | A nonsynonymous variation in MRP2/ABCC2 is associated with neurological adverse drug reactions of carbamazepine in patients with epilepsy. | Carbamazepine | ATP binding cassette subfamily C member 2 | Homo sapiens |
| 2 | A nonsynonymous variation in MRP2/ABCC2 is associated with neurological adverse drug reactions of carbamazepine in patients with epilepsy. | Carbamazepine | ATP binding cassette subfamily C member 2 | Homo sapiens |
| 3 | Therefore, genetic variations in the MRP2 gene may affect individual drug responses to the antiepileptic agent carbamazepine. | Carbamazepine | ATP binding cassette subfamily C member 2 | Homo sapiens |
| 4 | METHODS: Associations between MRP2 polymorphisms and the adverse drug reactions (ADRs) of carbamazepine were analyzed using an integrated population genetics and molecular functional approach. | Carbamazepine | ATP binding cassette subfamily C member 2 | Homo sapiens |
| 5 | Logistic regression analysis with multiple clinical variables indicated that the presence of A allele at the MRP2 c.1249G>A locus was an independent determinant of central nervous system ADR caused by carbamazepine. | Carbamazepine | ATP binding cassette subfamily C member 2 | Homo sapiens |
| 6 | The functional study using ATPase assay and FACScan flow cytometer indicated that carbamazepine was a substrate of MRP2 and that the 417I variation selectively reduced carbamazepine transport across the cell membrane. | Carbamazepine | ATP binding cassette subfamily C member 2 | Homo sapiens |
| 7 | CONCLUSION: These results strongly suggest that the A-allele of the MRP2 single nucleotide polymorphism c.1247G>A is associated with adverse neurological drug reactions to carbamazepine. | Carbamazepine | ATP binding cassette subfamily C member 2 | Homo sapiens |