Pub. Date : 2010 Mar 8
PMID : 20211007
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We therefore explored whether the known NFkappaB inhibitor celastrol could represent a suitable compound for decreasing Abeta production and accumulation in vivo. | celastrol | amyloid beta (A4) precursor protein | Mus musculus |
| 2 | METHODS: The effect of celastrol on amyloid precursor protein (APP) processing, Abeta production and NFkappaB activation was investigated by western blotting and ELISAs using a cell line overexpressing APP. | celastrol | amyloid beta (A4) precursor protein | Mus musculus |
| 3 | In addition, a reduction in Abeta plaque burden and microglial activation was observed in the brains of Tg PS1/APPsw following a chronic administration of celastrol. | celastrol | amyloid beta (A4) precursor protein | Mus musculus |
| 4 | CONCLUSIONS: Overall our data suggest that celastrol is a potent Abeta lowering compound that acts as an indirect BACE-1 inhibitor possibly by regulating BACE-1 expression level via an NFkappaB dependent mechanism. | celastrol | amyloid beta (A4) precursor protein | Mus musculus |