Pub. Date : 2010
PMID : 20208361
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Sanguinarine as a potent and specific inhibitor of protein phosphatase 2C in vitro and induces apoptosis via phosphorylation of p38 in HL60 cells. | sanguinarine | mitogen-activated protein kinase 14 | Homo sapiens |
| 2 | In vivo, sanguinarine showed cytotoxicity toward human promyelocytic leukemia cell line HL60, with an IC(50) value of 0.37 microM, and induced apoptosis through a caspase-3/7-dependent mechanism involving the phosphorylation of p38, a PP2Calpha substrate. | sanguinarine | mitogen-activated protein kinase 14 | Homo sapiens |
| 3 | The apoptosis activity induced by sanguinarine was partially inhibited by a p38 inhibitor, SB203580, and was involved in the phospho-p38 protein in HL60 cells. | sanguinarine | mitogen-activated protein kinase 14 | Homo sapiens |
| 4 | The apoptosis activity induced by sanguinarine was partially inhibited by a p38 inhibitor, SB203580, and was involved in the phospho-p38 protein in HL60 cells. | sanguinarine | mitogen-activated protein kinase 14 | Homo sapiens |