Title : Abscisic acid synergizes with rosiglitazone to improve glucose tolerance and down-modulate macrophage accumulation in adipose tissue: possible action of the cAMP/PKA/PPAR γ axis.

Pub. Date : 2010 Oct

PMID : 20207056






3 Functional Relationships(s)
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1 ABA and Ros synergistically increased PPAR gamma activity and pretreatment with a cAMP-inhibitor or a PKA-inhibitor abrogated ABA-induced PPAR gamma activation. Cyclic AMP peroxisome proliferator activated receptor gamma Mus musculus
2 CONCLUSIONS: ABA and Ros act synergistically to modulate PPAR gamma activity and macrophage accumulation in WAT and ABA enhances PPAR gamma activity through a membrane-initiated mechanism dependent on cAMP/PKA signaling. Cyclic AMP peroxisome proliferator activated receptor gamma Mus musculus
3 CONCLUSIONS: ABA and Ros act synergistically to modulate PPAR gamma activity and macrophage accumulation in WAT and ABA enhances PPAR gamma activity through a membrane-initiated mechanism dependent on cAMP/PKA signaling. Cyclic AMP peroxisome proliferator activated receptor gamma Mus musculus