PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20201775-1 2010 OBJECTIVE: To investigate the effects of black seed on the metabolic activities of CYP3A4 and CYP2D6 in human liver microsomes and in human subjects using dextromethorphan as a probe drug. Dextromethorphan 155-171 cytochrome P450 family 2 subfamily D member 6 Homo sapiens 94-100 20201775-10 2010 CONCLUSION: Black seed significantly inhibited CYP2D6 and CYP3A4 mediated metabolism of DEX in human liver microsomes and healthy human volunteers indicating that it has the potential to interact with CYP2D6 and CYP3A4 substrates. Dextromethorphan 88-91 cytochrome P450 family 2 subfamily D member 6 Homo sapiens 47-53 20201775-10 2010 CONCLUSION: Black seed significantly inhibited CYP2D6 and CYP3A4 mediated metabolism of DEX in human liver microsomes and healthy human volunteers indicating that it has the potential to interact with CYP2D6 and CYP3A4 substrates. Dextromethorphan 88-91 cytochrome P450 family 2 subfamily D member 6 Homo sapiens 201-207