Title : Specific roles of the p110alpha isoform of phosphatidylinsositol 3-kinase in hepatic insulin signaling and metabolic regulation.

Pub. Date : 2010 Mar 3

PMID : 20197055






1 Functional Relationships(s)
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1 Thus, deletion of p110alpha in liver results in markedly blunted insulin signaling with decreased generation of PIP(3) and loss of insulin activation of Akt, defects that could not be rescued by overexpression of p110beta. pip(3) phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Mus musculus