Title : Chemoprevention of 1,2-dimethylhydrazine-induced colon carcinogenesis by a non-steroidal anti-inflammatory drug, etoricoxib, in rats: inhibition of nuclear factor kappaB.

Pub. Date : 2009

PMID : 20192600






2 Functional Relationships(s)
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1 Studies of a nuclear transcription factor (NF-kB) and COX-2 by Western blot analysis and immunohistochemistry demonstrated expression of both to be elevated in the DMH treated group but reduced in the DMH + Etoricoxib group. 1,2-Dimethylhydrazine prostaglandin-endoperoxide synthase 2 Rattus norvegicus
2 Studies of a nuclear transcription factor (NF-kB) and COX-2 by Western blot analysis and immunohistochemistry demonstrated expression of both to be elevated in the DMH treated group but reduced in the DMH + Etoricoxib group. 1,2-Dimethylhydrazine prostaglandin-endoperoxide synthase 2 Rattus norvegicus