Title : Glycitein inhibits glioma cell invasion through down-regulation of MMP-3 and MMP-9 gene expression.

Pub. Date : 2010 Apr 15

PMID : 20188714






2 Functional Relationships(s)
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1 In support of this, treatment of MMP-3- or MMP-9-specific inhibitor significantly suppressed PMA-induced invasion of glioma cells. Tetradecanoylphorbol Acetate matrix metallopeptidase 3 Homo sapiens
2 Furthermore, glycitein suppresses PMA-induced phosphorylation of three types of MAP kinases, which are upstream signaling molecules in MMP gene expressions and NF-kappaB and AP-1 activities in glioma cells. Tetradecanoylphorbol Acetate matrix metallopeptidase 3 Homo sapiens