Title : CD73 on tumor cells impairs antitumor T-cell responses: a novel mechanism of tumor-induced immune suppression.

Pub. Date : 2010 Mar 15

PMID : 20179192






3 Functional Relationships(s)
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1 Because the ecto-5"-nucleotidase activity of CD73 catalyzes AMP breakdown to immunosuppressive adenosine, we hypothesized that CD73-generated adenosine prevents tumor destruction by inhibiting antitumor immunity. Adenosine Monophosphate 5' nucleotidase, ecto Mus musculus
2 Because the ecto-5"-nucleotidase activity of CD73 catalyzes AMP breakdown to immunosuppressive adenosine, we hypothesized that CD73-generated adenosine prevents tumor destruction by inhibiting antitumor immunity. Adenosine Monophosphate 5' nucleotidase, ecto Mus musculus
3 Because the ecto-5"-nucleotidase activity of CD73 catalyzes AMP breakdown to immunosuppressive adenosine, we hypothesized that CD73-generated adenosine prevents tumor destruction by inhibiting antitumor immunity. Adenosine Monophosphate 5' nucleotidase, ecto Mus musculus