Title : The prolyl isomerase Pin1 enhances HER-2 expression and cellular transformation via its interaction with mitogen-activated protein kinase/extracellular signal-regulated kinase kinase 1.

Pub. Date : 2010 Mar

PMID : 20179161






1 Functional Relationships(s)
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1 Furthermore, PD98059, a specific inhibitor of MEK1/2, and Juglone, a potent Pin1 inhibitor, markedly suppressed the expression of activator protein-2alpha and the HER-2 promoter activity induced by EGF or 12-O-tetradecanoylphorbol-13-acetate in MCF-7 cells. Tetradecanoylphorbol Acetate erb-b2 receptor tyrosine kinase 2 Homo sapiens