Title : Structural determinants of D-cycloserine efficacy at the NR1/NR2C NMDA receptors.

Pub. Date : 2010 Feb 17

PMID : 20164358






2 Functional Relationships(s)
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1 We have studied relative efficacies of NR1 agonists glycine and d-cycloserine (DCS), and found efficacy to be dependent on the NR2 subunit. Glycine glutamate ionotropic receptor NMDA type subunit 1 Homo sapiens
2 DCS shows partial agonism at NR1/NR2B but has higher relative efficacy than glycine at NR1/NR2C receptor. Glycine glutamate ionotropic receptor NMDA type subunit 1 Homo sapiens