Title : Flexibility of Catalytic Zinc Coordination in Thermolysin and HDAC8: A Born-Oppenheimer ab initio QM/MM Molecular Dynamics Study.

Pub. Date : 2009 Dec 2

PMID : 20161624






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Such distinct dynamics in the zinc coordination shell between two enzymes suggests that the catalytic role of Zinc in TLN and HDAC8 is likely to be different in spite of the fact that both catalyze the hydrolysis of amide bond. Amides histone deacetylase 8 Homo sapiens