Title : Comparison of the structures and peptide binding specificities of the BRCT domains of MDC1 and BRCA1.

Pub. Date : 2010 Feb 10

PMID : 20159462






2 Functional Relationships(s)
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1 Crystal structures of BRCA1 and MDC1 bound to tetrapeptide substrates reveal differences in the environment of conserved arginines (Arg1699 in BRCA1 and Arg1933 in MDC1) that determine the relative affinity for peptides with -COO(-) versus -CO-NH(2) termini. Arginine BRCA1 DNA repair associated Homo sapiens
2 Crystal structures of BRCA1 and MDC1 bound to tetrapeptide substrates reveal differences in the environment of conserved arginines (Arg1699 in BRCA1 and Arg1933 in MDC1) that determine the relative affinity for peptides with -COO(-) versus -CO-NH(2) termini. Arginine BRCA1 DNA repair associated Homo sapiens