Pub. Date : 2011 Jan
PMID : 20152998
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Addition of metformin to exogenous glucagon-like peptide-1 results in increased serum glucagon-like peptide-1 concentrations and greater glucose lowering in type 2 diabetes mellitus. | Metformin | glucagon | Homo sapiens |
| 2 | Addition of metformin to exogenous glucagon-like peptide-1 results in increased serum glucagon-like peptide-1 concentrations and greater glucose lowering in type 2 diabetes mellitus. | Metformin | glucagon | Homo sapiens |
| 3 | Mean area under curve (AUC) (0-180 minutes) plasma glucose responses were lowest after Metformin + GLP-1 (mean +- SEM, 1629 +- 90 mmol/[L min]) compared with GLP-1 (1885 +- 86 mmol/[L min], P < .002) and Metformin (2045 +- 115 mmol/[L min], P < .001). | Metformin | glucagon | Homo sapiens |
| 4 | Mean AUC for plasma DPP-4 activity was lower after Metformin + GLP-1 (1505 +- 2 mumol/[mL min], P < .001) and Metformin (1508 +- 2 mumol/[mL min], P < .002) compared with GLP-1 (1587 +- 3 mumol/[mL min]). | Metformin | glucagon | Homo sapiens |
| 5 | Mean AUC measures for plasma active GLP-1 concentrations were higher after Metformin + GLP-1 (820 x 104 +- 51 x 104 pmol/[L min]) compared with GLP-1 (484 x 104 +- 31 x 104 pmol/[L min], P < .001) and Metformin (419 x 104 +- 34 x 104 pmol/[L min], P < .001), respectively. | Metformin | glucagon | Homo sapiens |
| 6 | Mean AUC measures for plasma active GLP-1 concentrations were higher after Metformin + GLP-1 (820 x 104 +- 51 x 104 pmol/[L min]) compared with GLP-1 (484 x 104 +- 31 x 104 pmol/[L min], P < .001) and Metformin (419 x 104 +- 34 x 104 pmol/[L min], P < .001), respectively. | Metformin | glucagon | Homo sapiens |
| 7 | In patients with type 2 diabetes mellitus, metformin inhibits DPP-4 activity and thus increases active GLP-1 concentrations after subcutaneous injection. | Metformin | glucagon | Homo sapiens |
| 8 | Metformin enhances serum concentrations of injected active GLP-1(7-36)amide, and the combination results in added glucose-lowering potency. | Metformin | glucagon | Homo sapiens |